SATB2 (SATB Homeobox 2) is a Protein Coding gene. Diseases associated with SATB2 include Glass Syndrome and Cleft Palate, Isolated . Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding . An important paralog of this gene is SATB1. SATB2’s binding pattern is consistent with its role as a necessary specifier of cranial migratory neural crest differentiation in exo-mesenchymal tissues in the pharyngeal arches (which will develop into the jaw and teeth), and the consequent cleft palate defects observed in patients with mutated SATB2 in the human SATB2 syndrome (Zarate and Fish, 2017).

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Seattle (WA): University of Washington, Seattle; 1993-2020. Table 2. . Summary of the Most Common Clinical Findings in 76 Individuals with SATB2-Associated Syndrome. Anti-SATB2 antibody (ab34735) at 1 µg/ml + Mouse brain tissue lysate - total protein (0 days) at 10 µg Secondary IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/15000 dilution Performed under reducing conditions. Predicted band size: 83 kDa SATB2 Awareness Day. August 22 marks an amazing opportunity for SATB2-associated syndrome (SAS), the SATB2 Gene Foundation and the SATB2 Gene Trust UK. Because this day is one where we can all come together to spread the word about SAS. SATB2 Positive Control Slides, Product No. 384S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Physical form Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

25 Feb 2021 SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2  Detect Special AT-rich sequence-binding protein 2 using this rabbit polyclonal antibody, Anti-SATB2 Antibody validated for use in western blotting, IHC (Paraffin )  We need your help in understanding the impact of Ensembl in your research. Please take the EMBL-EBI impact survey that includes Ensembl (15 min).

SATB2 is a novel, sensitive marker for colorectal carcinoma. We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin. SATB2 and CDX2 IHC was performed on 159 primary (n=93) and metastatic (n=66) signet ring cell carcinomas of GI tract origin and 13 metastatic breast carcinomas with signet ring cell features.

HPA001042 Sigma-Aldrich Anti-SATB2 antibody produced in rabbit Prestige Antibodies ® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution . Synonym: Anti-APXL3, Anti-FLJ21474, Anti-KIAA1034, Anti-KIAA1481, Anti-SATB homeobox 2, Anti-SHRM, Anti-ShrmL, SATB2 Antibody - Anti-SATB2 antibody produced in rabbit, Satb2 Antibody Aims: Special AT-rich sequence-binding protein 2 (SATB2) is a transcriptional regulator with critical roles in brain, craniofacial and skeletal development. It has emerged as a key marker of lower gastrointestinal (GI) tract columnar epithelial and osteoblastic differentiation. Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. SATB2 is a nuclear matrix attachment region-binding transcription factor with developmental role in craniofacial, neural, and osteoblastic differentiation.

Selective nuclear expression in large intestine and subsets of neuronal cells in brain. SATB2: MIM i: 119540, phenotype 608148, gene: neXtProt i: NX_Q9UPW6: OpenTargets i: ENSG00000119042: Orphanet i: 251019, 2q32q33 microdeletion syndrome 251028, SATB2-associated syndrome due to a chromosomal rearrangement 576283, SATB2-associated syndrome due to a pathogenic variant: PharmGKB i: PA128394624: VEuPathDB i: HostDB:ENSG00000119042.16 SATB2_ENST00000260926, SATB2_ENST00000443023, SATB2_ENST00000457245, SATB2_ENST00000614512, SATB2_ENST00000428695 Sequences You can see various sequences for this gene: cDNA (ENST00000417098.5) Protein (SATB2) Transcript and protein aligned (ENST00000417098.5+SATB2) Gene fusions No fusions involving SATB2 Drug sensitivity data n/a SATB2 : Identification of colorectal carcinoma and rectal neuroendocrine tumors SATB2 - Overview: SATB2 Immunostain, Technical Component Only Skip to main content Addie is one of less than 200 people in the world diagnosed with SATB2 syndrome.She was hesitant to sit on the couch for an interview, so I joined Addie on t The SATB2 gene encodes a nuclear matrix DNA-binding protein that specifically binds to genomic nuclear matrix attachment regions and participates in transcription regulation and chromatin remodeling (summary by Leoyklang et al., 2013 ). SATB2-associated syndrome. Mutations in the SATB2 gene have been found to cause SATB2-associated syndrome.Individuals with this condition have intellectual disability and severe speech problems. SATB2 est une protéine codée chez l'humains par le gène SATB2. SATB2 est une protéine de liaison à l'ADN qui se lie spécifiquement à des régions d'attachement de la matrice nucléaire et qui est impliquée dans la regulation transcriptionnelle et du remodelage de la chromatine. SATB2 a été associé avec la survenue de la fente labiale chez des individus avec syndrome de microdélétion 2q32q33.
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Binds to DNA, at nuclear matrix- or scaffold-associated regions.

SATB2, Syndrome associé au gène SATB2, délétion ou microdélétion 2q33.1, mutation du gène SATB2, AFSATB2, association française du satb2, Anomalie genetique SATB2 | Association Française du SATB2 SATB2 Awareness Day. August 22 marks an amazing opportunity for SATB2-associated syndrome (SAS), the SATB2 Gene Foundation and the SATB2 Gene Trust UK. Because this day is one where we can all come together to spread the word about SAS. SATB2 - Books Result. 1. Cantrell A, Croot E, Johnson M, et al.
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Hum. Genet. 2013; 132(12):1383-93. SATB2 Antibody (SATBA4B10) is available as the non-conjugated anti-SATB2 antibody.

Diseases associated with SATB2 include Glass Syndrome and Cleft Palate, Isolated .

Access to primary and community health-care services for people 16 years and over with intellectual disabilities: a mapping and targeted systematic review. Southampton (UK): NIHR Journals Library; 2020 Jan. (Health Services and Delivery Research, No. 8.5.) SATB2 (SATB homeobox 2) is an AT rich DNA-binding protein. It is a homologue of SATB1 protein. This gene is localized to human chromosome 2q33.1, and is highly conserved across different species. Immunogen SATB homeobox 2 recombinant protein epitope signature tag (PrEST) Application Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.