Bsa protein
Bsa protein
89:171–184. The in ovo chick embryo chorioallantoic membrane (CAM) assay showed that anisomelic acid inhibited the tumor growth of the cervical cancer SiHa cells. AA is revealed to hold a novel action modality based on specific targeting of the HPV oncoproteins, which restores p53-mediated growth arrest and induces apoptosis by terminating E6-mediated cIAP2 stabilization. Dealing with heartburn and stomach acid troubles is an uncomfortable condition that nearly everyone experiences from time. For some people, it's a sign of gastroesophageal reflux disease (GERD).
Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA Anisomelic acid, one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane-type diterpenoid, which can be synthesized chemically . Anisomelic acid has also been previously isolated from A. malabarica and A. indica and it has been shown to be cytotoxic to KB cells [5, 6]. Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells. 8 Recently, we have shown that AA induces apoptosis and cause cell cycle arrest in SiHa cervical cancer cells by specifically down-regulating the Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells.
Recently, we have studied the mode of action of AA-mediated apoptosis, indicating Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown.
Fang Cheng - CONVERIS forskningsinformationssystem - Converis
(in col. with Prof. Erikson's team).
Fang Cheng - CONVERIS forskningsinformationssystem - Converis
19 Feb 2018 acetoxy malabaric acid and anisomelol are isolated as macrocyclic diterpenes, while anisomelic acid, ovatodlolide are as diterpenoid lactones, 19 Dec 2013 Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic 8 Jul 2014 acid activates the PKR pathway and induces apoptosis through diterpenoid anisomelic acid causes depletion of E6 and E7 viral.
Preethy Paul. Ali …
WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201
Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica, 7 which we have previously shown to be cytotoxic to oral and cervical cancer cells.
Amanda ellervik
petroleum ether extract of plant contains a triterpenic acid known as betulinic acid [3] while the hexane extract consists of β-sitosterol and diterpenoids (ovatodiolide and anisomelic acid) [4].
Anisomelic acid | C20H26O4 | CID 5358705 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities
2019-12-30
2019-12-30
Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown.
Posten paket kostnad
flyttanmälan skatteverket post
rättsmedicin flemingsberg
sacrococcygealt teratom
teckenspråk djur bilder
Targeted delivery of a novel anticancer compound anisomelic
The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a co-solvents or surfactant or a combination thereof. Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson.
Trollhattan forsorjningsstod
avstalla bilen pa natet
Publikationslista för Magnus Odén - Publication List : Epress : LiU.se
Preethy Paul. Ali Alshatwi. Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Scientific Reports , Mar 2020 Rajendran Senthilkumar , Yury Brusentsev , Preethy Paul , Parthiban Marimuthu , Fang Cheng , Patrik C. Eklund , John Elias Eriksson Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica.
FI126047B - Pharmaceutical compositions of anisomelic acid and
Anisomelic acid was present in the crude n-hexane and chloroform extracts as seen in the RP-HPLC, and it reveals that AA is one of the major compounds in this plant. Since the trends produced by the extracts [ 11 ] and the pure compound AA were comparable, we are led to conclude that AA is the principal factor in the extracts, or one of the factors responsible for the observed cytotoxic effect. WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201 Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP).
89:171–184.